Smart design for a flexible, functionalized and electroresponsive hybrid platform based on poly(3,4-ethylenedioxythiophene) derivatives to improve cell viability
| Autor: | Carlos Alemán, Lourdes Franco, Jordi Puiggalí, Elaine Armelin, Sonia Lanzalaco, Ioan Cianga, Anca D. Bendrea, Brenda G. Molina, Pau Turon, Luis J. del Valle, Luminita Cianga |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química, Universitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers, Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies, Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Cell Survival Polymers Polyesters Biomedical Engineering Nanoparticle engineering.material Polypropylenes chemistry.chemical_compound Enginyeria química [Àrees temàtiques de la UPC] Coated Materials Biocompatible Coating PEDOT:PSS Cell Adhesion Humans Tissue engineering General Materials Science Pliability Cell Proliferation Tissue Engineering Tissue Scaffolds Electric Conductivity General Chemistry General Medicine Bridged Bicyclo Compounds Heterocyclic Polímers Surface coating Enginyeria de teixits Chemical engineering chemistry Polymerization Wettability engineering Nanoparticles Surface modification Layer (electronics) Poly(3 4-ethylenedioxythiophene) HeLa Cells |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| ISSN: | 2050-7518 2050-750X |
| Popis: | Development of smart functionalized materials for tissue engineering has attracted significant attention in recent years. In this work we have functionalized a free-standing film of isotactic polypropylene (i-PP), a synthetic polymer that is typically used for biomedical applications (e.g. fabrication of implants), for engineering a 3D all-polymer flexible interface that enhances cell proliferation by a factor of ca. three. A hierarchical construction process consisting of three steps was engineered as follows: (1) functionalization of i-PP by applying a plasma treatment, resulting in i-PPf; (2) i-PPf surface coating with a layer of polyhydroxymethy-3,4-ethylenedioxythiophene nanoparticles (PHMeEDOT NPs) by in situ chemical oxidative polymerization of HMeEDOT; and (3) deposition on the previously activated and PHMeEDOT NPs coated i-PP film (i-PPf/NP) of a graft conjugated copolymer, having a poly(3,4-ethylenedioxythiophene) (PEDOT) backbone, and randomly distributed short poly(e-caprolactone) (PCL) side chains (PEDOT-g-PCL), as a coating layer of ~9 µm in thickness. The properties of the resulting bioplatform, which can be defined as a robust macroscopic composite coated with a “molecular composite”, were investigated in detail, and both adhesion and proliferation of two human cell lines have been evaluated, as well. The results demonstrate that the incorporation of the PEDOT-g-PCL layer significantly improves cell attachment and cell growth not only when compared to i-PP but also with respect to the same platform coated with only PEDOT, constructed in a similar manner, as a control. |
| Databáze: | OpenAIRE |
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