Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats
| Autor: | Arash Afrooziyan, Moslem Najafi, Alireza Garjani, Hossein Nazemiyeh, Nasrin Maleki-Dizaji, Ali Kharazmkia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Inotrope Cardiotonic Agents medicine.medical_treatment Intraperitoneal injection Blood Pressure Pharmacology Contractility Random Allocation medicine Animals Rats Wistar Lung Antihypertensive Agents Fatigue Cyanosis Heart Failure Analysis of Variance Monocrotaline biology Traditional medicine Plant Extracts business.industry Heart General Medicine lcsh:Other systems of medicine Cynodon dactylon medicine.disease biology.organism_classification lcsh:RZ201-999 Myocardial Contraction Rats Disease Models Animal Preload Dyspnea Blood pressure Cynodon Complementary and alternative medicine Heart failure business Rhizome Phytotherapy Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine, Vol 9, Iss 1, p 28 (2009) BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| Popis: | Background The rhizomes of Cynodon dactylon are used for the treatment of heart failure in folk medicine. In the present study, we investigated the effects of hydroalcoholic extract of C. dactylon rhizomes on cardiac contractility in normal hearts and on cardiac functions in right-heart failure in rats. Methods Right-heart failure was induced by intraperitoneal injection of monocrotaline (50 mg/kg). Two weeks later, the animals were treated orally with different doses of the extract for fifteen days. At the end of the experiments cardiac functions and markers of myocardial hypertrophy were measured. Results The treated rats showed very less signs of fatigue, peripheral cyanosis and dyspnea. The survival rate was high in the extract treated groups (90%). Administration of C. dactylon in monocrotaline-injected rats led to profound improvement in cardiac functions as demonstrated by decreased right ventricular end diastolic pressure (RVEDP) and elevated mean arterial pressure. RVdP/dtmax, and RVdP/dt/P as indices of myocardial contractility were also markedly (p < 0.001; using one way ANOVA) increased by the extract. The extract reduced heart and lung congestion by decreasing tissue wet/dry and wet/body weight ratios (p < 0.01). In the isolated rat hearts, the extract produced a remarkable (P < 0.001) positive inotropic effect concomitant with a parallel decrease in LVEDP. Conclusion The results of this study indicated that C. dactylon exerted a strong protective effect on right heart failure, in part by positive inotropic action and improving cardiac functions. |
| Databáze: | OpenAIRE |
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