Sex differences in renin-angiotensin-aldosterone system affect extracellular volume in healthy subjects
| Autor: | Gerjan Navis, Folkert W. Visser, Gozewijn D. Laverman, Tsjitske J. Toering, A.H. Jan Danser, Anne Marijn van der Graaf, Marijke M. Faas, Christina M. Gant, A. Titia Lely |
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| Přispěvatelé: | Reproductive Origins of Adult Health and Disease (ROAHD), Translational Immunology Groningen (TRIGR), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Value, Affordability and Sustainability (VALUE), Internal Medicine |
| Rok vydání: | 2017 |
| Předmět: |
Male
Physiology Blood Pressure 030204 cardiovascular system & hematology Essential hypertension Renin-Angiotensin System chemistry.chemical_compound Random Allocation 0302 clinical medicine Extracellular fluid Adrenal Glands 030212 general & internal medicine ESSENTIAL-HYPERTENSION CONVERTING-ENZYME-INHIBITION Infusions Intravenous Aldosterone Fluid Shifts media_common FLUID VOLUME Cross-Over Studies Angiotensin II Diet Sodium-Restricted Water-Electrolyte Balance Healthy Volunteers Sex Female Renin-angiotensin system MENSTRUAL-CYCLE Extracellular volume RENAL-RESPONSE Adult medicine.medical_specialty Ambulatory blood pressure media_common.quotation_subject Urology Affect (psychology) 03 medical and health sciences Young Adult AGE Sex Factors Body Water Internal medicine Renin–angiotensin system medicine Journal Article Humans Healthy volunteers Menstrual cycle GENDER-DIFFERENCES AMBULATORY BLOOD-PRESSURE Sodium Dietary medicine.disease Sexual dimorphism SODIUM Endocrinology chemistry DIMORPHISM |
| Zdroj: | American journal of physiology-Renal physiology, 314(5), F873-F878. AMER PHYSIOLOGICAL SOC American Journal of Physiology-Renal Physiology, 314(5), F873. American Physiological Society American Journal of Physiology-Renal Physiology, 314(5), F873-F878. American Physiological Society |
| ISSN: | 1522-1466 1931-857X 0363-6127 |
| Popis: | Several studies reported sex differences in aldosterone. It is unknown whether these differences are associated with differences in volume regulation. Therefore we studied both aldosterone and extracellular volume in men and women on different sodium intakes. In healthy normotensive men ( n = 18) and premenopausal women ( n = 18) we investigated plasma aldosterone, blood pressure, and extracellular volume (125I-iothalamate), during both low (target intake 50 mmol Na+/day) and high sodium intake (target intake 200 mmol Na+/day) in a crossover setup. Furthermore, we studied the adrenal response to angiotensin II infusion (0.3, 1.0, and 3.0 ng·kg−1·min−1for 1 h) on both sodium intakes. Men had a significantly higher plasma aldosterone, extracellular volume, and systolic blood pressure than women during high sodium intake ( P < 0.05). During low sodium intake, extracellular volume and blood pressure were higher in men as well ( P < 0.05), whereas the difference in plasma aldosterone was no longer significant ( P = 0.252). The adrenal response to exogenous angiotensin II was significantly lower in men than in women on both sodium intakes. Constitutive sex differences in the regulation of aldosterone, characterized by a higher aldosterone and a lower adrenal response to exogenous angiotensin II infusion in men, are associated with a higher extracellular volume and blood pressure in men. These findings suggest that sex differences in the regulation of aldosterone contribute to differences in volume regulation between men and women. |
| Databáze: | OpenAIRE |
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