Altered ex vivo expression of caspase 8, caspase 9, and Bcl-2 is associated with T-cell hyporeactivity in patients with paracoccidioidomycosis
| Autor: | Antonio Carlos Francisconido do Valle, Camila R. Cacere, Maria José Soares Mendes-Giannini, Alberto José da Silva Duarte, Gil Benard |
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| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Interleukin 2 Adult T cell T-Lymphocytes Clinical Biochemistry Immunology Biology Caspase 8 Immune tolerance Young Adult Immune system medicine Immune Tolerance Immunology and Allergy Humans Aged Caspase-9 Paracoccidioidomycosis Middle Aged medicine.disease Caspase 9 medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Cancer research biology.protein Interleukin-2 Immune Mechanisms Ex vivo medicine.drug |
| Zdroj: | Clinical and vaccine immunology : CVI. 16(6) |
| ISSN: | 1556-679X |
| Popis: | To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis. |
| Databáze: | OpenAIRE |
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