Limitations of Fat-Free Mass for the Assessment of Muscle Mass in Obesity

Autor: Markus Both, Anja Bosy-Westphal, Wiebke Braun, Kristin Klückmann, Bjørn Keller Jensen, Manfred J. Müller, Corinna Geisler
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Systematic error
Male
Sarcopenia
Health (social science)
0302 clinical medicine
Absorptiometry
Photon
Electric Impedance
lcsh:RC620-627
Organ Size
Middle Aged
Plethysmography
Fat-free mass
lcsh:Nutritional diseases. Deficiency diseases
Adipose Tissue
Cardiology
Body Composition
Female
Bioelectrical impedance analysis
lcsh:Nutrition. Foods and food supply
Four-compartment model
Research Article
Adult
medicine.medical_specialty
Adolescent
030209 endocrinology & metabolism
lcsh:TX341-641
Composition analysis
Muscle mass
03 medical and health sciences
Skeletal muscle mass
Young Adult
Fat free mass
Physiology (medical)
Internal medicine
medicine
Humans
Body Weights and Measures
Obesity
Muscle
Skeletal
Aged
030109 nutrition & dietetics
business.industry
Reproducibility of Results
medicine.disease
business
human activities
Zdroj: Obesity Facts, Vol 12, Iss 3, Pp 307-315 (2019)
Popis: Background: A high amount of adipose tissue limits the accuracy of methods for body composition analysis in obesity. Objectives: The aim was to quantify and explain differences in fat-free mass (FFM) (as an index of skeletal muscle mass, SMM) measured with bioelectrical impedance analysis (BIA), dual energy X-ray absorptiometry (DXA), air displacement plethysmography (ADP), and deuterium dilution in comparison to multicompartment models, and to improve the results of BIA for obese subjects. Methods: In 175 healthy subjects (87 men and 88 women, BMI 20–43.3 kg/m2, 18–65 years), FFM measured by these methods was compared with results from a 3- (3C) and a 4-compartment (4C) model. FFM4C was compared with SMM measured by magnetic resonance imaging. Results: BIA and DXA overestimated and ADP underestimated FFM in comparison to 3C and 4C models with increasing BMI (all p < 0.001). ­Differences were largest for DXA. In obesity, BIA results were improved: valuecorrected = ­valueuncorrected – a(BMI – 30 kg/m2), a = 0.256 for FFM and a = 0.298 for SMM. SMM accounts for 45% of FFM in women and 49% in men. Conclusions: In obesity, the use of FFM is limited by a systematic error of reference methods. In addition, SMM accounts for about 50% of FFM only. Corrected measurement of SMM by BIA can overcome these drawbacks.
Databáze: OpenAIRE
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