Glucocorticoids, the evolution of the stress-response, and the primate predicament
| Autor: | Robert M. Sapolsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Neurophysiology and neuropsychology
Physiology Evolution Neurosciences. Biological psychiatry. Neuropsychiatry Primate psychosocial stress Stress Biochemistry Life history theory Fight-or-flight response 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology biology.animal Primate RC346-429 Molecular Biology biology Endocrine and Autonomic Systems QP351-495 Stressor Vertebrate 030227 psychiatry Article from the Special Issue on Evolution of the Stress Response Edited by Seema Bhatnagar Glucocorticoid secretion Evolutionary biology Psychosocial stress Fish Neurology. Diseases of the nervous system 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Neurobiology of Stress Neurobiology of Stress, Vol 14, Iss, Pp 100320-(2021) |
| ISSN: | 2352-2895 |
| Popis: | The adrenocortical stress-response is extraordinarily conserved across mammals, birds, fish, reptiles, and amphibians, suggesting that it has been present during the hundreds of millions of years of vertebrate existence. Given that antiquity, it is relatively recent that primate social complexity has evolved to the point that, uniquely, life can be dominated by chronic psychosocial stress. This paper first reviews adrenocortical evolution during vertebrate history. This produces a consistent theme of there being an evolutionary tradeoff between the protective effects of glucocorticoids during an ongoing physical stressor, versus the adverse long-term consequences of excessive glucocorticoid secretion; how this tradeoff is resolved depends on particular life history strategies of populations, species and vertebrate taxa. This contrasts with adrenocortical evolution in socially complex primates, who mal-adaptively activate the classic vertebrate stress-response during chronic psychosocial stress. This emphasizes the rather unique and ongoing selective forces sculpting the stress-response in primates, including humans. |
| Databáze: | OpenAIRE |
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