Biochemical Changes in Progressive Muscular Dystrophy
| Autor: | Uma Srivastava, M.A. Mukundan, Anima Devi |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Protein metabolism Medicine (miscellaneous) Creatine Lens protein Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Choline Muscular dystrophy Nutrition and Dietetics biology RNA Skeletal muscle Metabolism medicine.disease Sensory Systems Uridine Ophthalmology Endocrinology medicine.anatomical_structure Biochemistry chemistry biology.protein Nucleic acid Creatine kinase Leucine Adenosine triphosphate DNA |
| Zdroj: | The Journal of Nutrition. 86:298-302 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/86.3.298 |
| Popis: | A study on nucleic acid and protein metabolism in the lenses of vitamin E-deficient rabbits and hereditary dystrophie mice was undertaken. These animals showed a gradual decrease in body weight, lens weight and concentration of lens protein with the progress of the disease. In the dystrophic lenses, there was no significant difference in the water content, but the concentrations of both nucleic acids (DNA and RNA) increased constantly. Increase in the incorporation of [14C]thymidine into DNA of the soluble extracts and of [14C]uridine into the DNA of the perchloric acid-insoluble fractions of the dystrophic lenses was also observed. The soluble fractions of the lenses of dystrophic mice exhibited a maximum increase in RNA content, and the incorporation of [14C]leucine into the lens proteins of dystrophic mice was increased significantly. Amino acyl arylamidase and leucine amino peptidase activity of the dystrophic mice lenses was also increased considerably. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|