Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma
| Autor: | Yueqi Wang, Hongtao Pan, Tao Suo, Zhilong Ai, Houbao Liu, Sai-xiong Tong, Chentao Lv |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Down-Regulation Antineoplastic Agents Apoptosis Biology Transfection Stem cell marker Arsenicals chemistry.chemical_compound fluids and secretions Arsenic Trioxide Antigens CD Cell Line Tumor medicine Carcinoma Humans AC133 Antigen RNA Messenger Arsenic trioxide neoplasms Protein kinase B Glycoproteins Gallbladder Oxides medicine.disease carbohydrates (lipids) medicine.anatomical_structure Oncology chemistry Drug Resistance Neoplasm Cell culture embryonic structures Neoplastic Stem Cells cardiovascular system Cancer research Gallbladder Neoplasms Peptides Proto-Oncogene Proteins c-akt Plasmids Signal Transduction |
| Zdroj: | Cancer Letters. |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2011.06.035 |
| Popis: | CD133+ tumor cells are responsible for the initiation, propagation and recurrence of tumors, which raises the question of how to effectively target CD133+ tumor cells. Arsenic trioxide (As2O3) has considerable efficacy in treating solid tumors with induction of apoptosis. Here, we found that purified CD133+ gallbladder carcinoma cells are highly resistant to conventional chemotherapy. However, As2O3 effectively induces CD133+ gallbladder carcinoma cells apoptosis. Treatment with As2O3 reduces CD133 expression at transcriptional levels. Furthermore, the ectopic expression of CD133 attenuated the apoptotic effect of As2O3 on cells through activation of AKT signaling pathways. Collectively, As2O3 effectively targets CD133 in gallbladder carcinoma, providing a new mechanism of As2O3-induced cell apoptosis and a better understanding of drug resistance in gallbladder carcinoma. |
| Databáze: | OpenAIRE |
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