Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo
| Autor: | Barry D. Michael, Andrew I. Minchinton, Juliana Denekamp, N H Terry, Michael R.L. Stratford, F.A. Stewart, C E Smithen |
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| Rok vydání: | 1982 |
| Předmět: |
Male
Drug Radiation-Sensitizing Agents Cancer Research Misonidazole Cell Survival media_common.quotation_subject Mice Inbred Strains Pharmacology Biology Hypoxic cell Mice chemistry.chemical_compound In vivo medicine Animals Bioassay Sensitization Skin media_common Dose-Response Relationship Drug Neurotoxicity Dose-Response Relationship Radiation medicine.disease Oxygen medicine.anatomical_structure Oncology chemistry Nitroimidazoles Toxicity Female Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1982.40 |
| Popis: | The survival of epidermal cells in vivo has been used to assess potential radiosensitizers. Mouse skin was made acutely hypoxic for the irradiations, to give radioprotection by a factor of 2.7-3.0. Several concentrations of each drug were used to determine whether any of them were more effective sensitizers than misonidazole. The SER at each concentration was determined from radiobiological dose-response curves. The blood concentration and toxicity of the compounds were also determined. The sensitizing efficiency, assessed in several ways, indicated that only Ro 03-8799 gave significantly greater sensitization than misonidazole, and then only when assessed by comparing the compounds on the basis of equimolar blood concentrations. If the comparison of efficiency was made in terms of LD50 the ranking order change. The need for a more clinically relevant test of peripheral neurotoxicity is stressed. |
| Databáze: | OpenAIRE |
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