From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain
| Autor: | Yumiko Hatanaka, Yan Zhu, Yoshiaki Kita, Fujio Murakami, Makio Torigoe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Central Nervous System
cortical interneuron Nervous system non-directed migration precerebellar neuron Neuronal migration Golgi Apparatus General Physics and Astronomy Review Biology Mice Cell Movement Interneurons medicine Animals Humans Axon Process (anatomy) Brain function Cell Nucleus Neurons neuronal migration Dynamics (mechanics) Brain radial migration General Medicine tangential migration Rats Rhombencephalon medicine.anatomical_structure nervous system Neuronal circuits Neuron General Agricultural and Biological Sciences Neuroscience |
| Zdroj: | Proceedings of the Japan Academy. Series B, Physical and Biological Sciences |
| ISSN: | 1349-2896 0386-2208 |
| DOI: | 10.2183/pjab.92.1 |
| Popis: | Neuronal migration is crucial for the construction of the nervous system. To reach their correct destination, migrating neurons choose pathways using physical substrates and chemical cues of either diffusible or non-diffusible nature. Migrating neurons extend a leading and a trailing process. The leading process, which extends in the direction of migration, determines navigation, in particular when a neuron changes its direction of migration. While most neurons simply migrate radially, certain neurons switch their mode of migration between radial and tangential, with the latter allowing migration to destinations far from the neurons’ site of generation. Consequently, neurons with distinct origins are intermingled, which results in intricate neuronal architectures and connectivities and provides an important basis for higher brain function. The trailing process, in contrast, contributes to the late stage of development by turning into the axon, thus contributing to the formation of neuronal circuits. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|