Human Umbilical Cord Blood CD34-Positive Cells as Predictors of the Incidence and Short-Term Outcome of Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot Study
| Autor: | Sahar M A Hassanein, Moustafa El Houssinie, Abir Ibrahim, Mohamed Hassan Nasr Eldin, Hanaa A. Amer, Adel E. Abdelhamid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Encephalopathy full-term neonates CD34 Thompson score Gastroenterology Umbilical cord Hobel risk score 03 medical and health sciences 0302 clinical medicine stem cells 030225 pediatrics Internal medicine medicine mononuclear layer perinatal asphyxia Framingham Risk Score business.industry Incidence (epidemiology) Nucleated Red Blood Cell medicine.disease Perinatal asphyxia medicine.anatomical_structure Neurology Anesthesia Original Article Neurology (clinical) Stem cell business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neurology (Seoul, Korea) |
| ISSN: | 2005-5013 1738-6586 |
| Popis: | BACKGROUND AND PURPOSE Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neurological handicap in developing countries. Human umbilical cord blood (hUCB) CD34-positive (CD34⁺) stem cells exhibit the potential for neural repair. We tested the hypothesis that hUCB CD34⁺ stem cells and other cell types [leukocytes and nucleated red blood cells (NRBCs)] that are up-regulated during the acute stage of perinatal asphyxia (PA) could play a role in the early prediction of the occurrence, severity, and mortality of HIE. METHODS This case-control pilot study investigated consecutive neonates exposed to PA. The hUCB CD34⁺ cell count in mononuclear layers was assayed using a flow cytometer. Twenty full-term neonates with PA and 25 healthy neonates were enrolled in the study. RESULTS The absolute CD34⁺ cell count (p=0.02) and the relative CD34⁺ cell count (CD34⁺%) (p |
| Databáze: | OpenAIRE |
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