Antinociceptive Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats
| Autor: | Jane W Mbiri, Mathew N Piero, Sichangi Kasili, Wilton Mbinda, Patrick D Kisangau, Michael N Musila |
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| Rok vydání: | 2016 |
| Předmět: |
Terminalia brownii
biology Traditional medicine business.industry Analgesic Terminalia Pharmacology biology.organism_classification complex mixtures 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine Nociception Diclofenac Late phase visual_art medicine visual_art.visual_art_medium Bark business Licking medicine.drug |
| Zdroj: | The Lens |
| ISSN: | 2167-0846 |
| DOI: | 10.4172/2167-0846.1000261 |
| Popis: | Background: The barks of the medicinal plant, Terminalia brownii, are widely used in African folk medicine for the management of pain. However, this ethno-medicinal allegation has not been scientifically validated. This study was therefore designed to verify the antinociceptive potential of the methanolic bark extract of T. brownii in Wistar rats (Rattus novegicus). Methods: Fresh barks of T. brownii were obtained from Kitui County, Kenya with the guidance of a residential herbalist. The study used thirty 2-3 months old male Wistar rats, weighing 140-150 g. The rats were randomly divided into 6 groups; three control groups (normal, negative and positive) and three experimental groups (50, 100 and 150 mg/kg extract treatment). Each group had five rats. The analgesic properties of the extract were evaluated on formalin-induced pain and diclofenac was used as the standard drug. Results: The methanolic bark extracts of T. brownii demonstrated significant antinociceptive activity (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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