Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m-fluorophenylalanine-peptide conjugates
| Autor: | Jeffrey C. Boehm, Sarah F. Grappel, Rajanikant J. Mehta, William D. Kingsbury |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
chemistry.chemical_classification
Dipeptide biology Chemistry Stereochemistry Phenylalanine Biological Transport Peptide Tripeptide biology.organism_classification Corpus albicans Minimum inhibitory concentration chemistry.chemical_compound Biochemistry Peptide transport Drug Discovery Molecular Medicine Antagonism Candida albicans Oligopeptides Candida |
| Zdroj: | Journal of Medicinal Chemistry. 26:1725-1729 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | A series of di- and tripeptides containing D- and L-m-fluorophenylalanine was prepared and tested in vitro for the ability to inhibit the growth of the yeast Candida albicans. The results demonstrate that peptides containing L-m-fluorophenylalanine inhibited the growth of C. albicans with minimum inhibitory concentrations (MIC's) ranging from 0.5 to 63 micrograms/mL. The parent L-m-fluorophenylalanine and peptides containing D-m-fluorophenylalanine were inactive (MIC greater than 250 micrograms/mL) in these tests. The results of competitive antagonism studies support peptide transport mediated entry of the inhibitory peptides, followed by release of L-m-fluorophenylalanine inside the cell. |
| Databáze: | OpenAIRE |
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