Coordinate hormonal and synaptic regulation of vasopressin messenger RNA
| Autor: | Teresa M. O'kane, Frank Baldino, Sandra Fitzpatrick-Mcelligott, Betty Wolfson |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Vasopressins Central nervous system Peptide hormone Biology Oxytocin Internal medicine Gene expression medicine Animals RNA Messenger Neurons Messenger RNA Multidisciplinary Adrenalectomy Rats Inbred Strains Rats Endocrinology medicine.anatomical_structure Phenotype nervous system Gene Expression Regulation Hypothalamus Synapses Nucleus hormones hormone substitutes and hormone antagonists medicine.drug Paraventricular Hypothalamic Nucleus |
| Zdroj: | Science (New York, N.Y.). 241(4868) |
| ISSN: | 0036-8075 |
| Popis: | Previous studies have shown that adrenalectomy augments arginine vasopressin (AVP) messenger RNA levels in the adult paraventricular nucleus. It is now demonstrated that unilateral lesions in the lateral septal nucleus enhance the adrenalectomy-induced expression of AVP mRNA. This effect was entirely ipsilateral to the lesion and most prominent in the rostral paraventricular nucleus and related nuclei. Moreover, AVP and AVP mRNA were found to be colocalized with oxytocin in a few neurons. These results indicate that mRNA expression is modulated by synaptic influences and raise the possibility that synaptically mediated selection of neuronal phenotypes is a dynamic feature of the mature central nervous system. |
| Databáze: | OpenAIRE |
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