The Different Roles of Glucocorticoids in the Hippocampus and Hypothalamus in Chronic Stress-Induced HPA Axis Hyperactivity
| Autor: | Hoonkyo Suh, Qi Gang Zhou, Chen Chen, Hai Yin Wu, Huan Li, Xiao Liu, Xing Jing, Zhou Han, Meng Ying Liu, Li Juan Zhu, Hai Hui Zhou, Dong-Ya Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Cell signaling Medical Physics lcsh:Medicine Hippocampus Pituitary-Adrenal System Neural Homeostasis Nitric Oxide Synthase Type I Signal transduction Feedback regulation Biochemistry Mechanical Treatment of Specimens chemistry.chemical_compound Mineralocorticoid receptor Transmembrane signaling Molecular Cell Biology Medicine and Health Sciences Chronic stress lcsh:Science Mice Knockout Mice Inbred ICR Multidisciplinary Depression Physics Neurochemistry Transcriptional signaling Signaling Cascades Electroporation Neuronal nitric oxide Specimen Disruption Hypothalamus Physical Sciences hormones hormone substitutes and hormone antagonists Research Article medicine.medical_specialty endocrine system Cell biology Hypothalamo-Hypophyseal System Mice 129 Strain Neural Networks Biology Research and Analysis Methods Stress Signaling Cascade Nitric oxide Neuropsychology Internal medicine medicine Animals Glucocorticoids Biology and life sciences lcsh:R Nuclear signaling Mice Inbred C57BL Endocrinology chemistry nervous system Specimen Preparation and Treatment cGMP signaling Chronic Disease lcsh:Q Stress Psychological Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 5, p e97689 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Hypothalamus-pituitary-adrenal (HPA) hyperactivity is observed in many patients suffering from depression and the mechanism underling the dysfunction of HPA axis is not well understood. Chronic stress has a causal relationship with the hyperactivity of HPA axis. Stress induces the over-synthesis of glucocorticoids, which will arrive at all the body containing the brain. It is still complicated whether glucocorticoids account for chronic stress-induced HPA axis hyperactivity and in which part of the brain the glucocorticoids account for chronic stress-induced HPA axis hyperactivity. Here, we demonstrated that glucocorticoids were indispensable and sufficient for chronic stress-induced hyperactivity of HPA axis. Although acute glucocorticoids elevation in the hippocampus and hypothalamus exerted a negative regulation of HPA axis, we found that chronic glucocorticoids elevation in the hippocampus but not in the hypothalamus accounted for chronic stress-induced hyperactivity of HPA axis. Chronic glucocorticoids exposure in the hypothalamus still exerted a negative regulation of HPA axis activity. More importantly, we found mineralocorticoid receptor (MR) - neuronal nitric oxide synthesis enzyme (nNOS) - nitric oxide (NO) pathway mediated the different roles of glucocorticoids in the hippocampus and hypothalamus in regulating HPA axis activity. This study suggests that the glucocorticoids in the hippocampus play an important role in the development of HPA axis hyperactivity and the glucocorticoids in the hypothalamus can't induce hyperactivity of HPA axis, revealing new insights into understanding the mechanism of depression. |
| Databáze: | OpenAIRE |
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