Assessment of the relationship between neutrophil lymphocyte ratio and prognostic factors in non-metastatic colorectal cancer
| Autor: | Ahmet Balik, Latif Yilmaz, Alper Aytekin, Zehra Bozdag, Ersin Borazan, Ilyas Baskonus, Muhsin Elci, Muhammed Kasım Arık |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Proportional hazards model Lymphovascular invasion business.industry Perineural invasion Retrospective cohort study medicine.disease Colorectal surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Stage (cooking) Adverse effect business Original Investigation |
| Zdroj: | Turkish Journal of Surgery. 33:185-189 |
| ISSN: | 2564-7032 2564-6850 |
| DOI: | 10.5152/turkjsurg.2017.3528 |
| Popis: | Objective Neutrophil-lymphocyte ratio still has a limited clinical use due to many non-cancer factors affecting neutrophils or lymphocytes in the present time. We aimed to evaluate the association between preoperative neutrophil-lymphocyte ratio and poor prognostic factors after curative elective colorectal surgery. Material and methods This clinical retrospective study was initiated with 95 patients, who had a curative surgical resection between 2003 and 2013. The patients were divided into two groups based on the preoperative neutrophil-lymphocyte ratio cut-off value above and below 3. The groups were compared for tumor localization, diameter, and staging; the histopathological perineural invasion; lymphovascular invasion; and overall survival. Univariate and multivariate Cox regression analyses were used to determine the role of neutrophil-lymphocyte ratio after stratification by several clinicopathological factors. Results The mean age of patients was 59.79±1.48 (range, 23-90) years, and median follow-up period was 20.77±14.85 months. There was no significant difference in perineural or lymphovascular invasion, tumor size, stage, age, sex, and tumor location between the groups [Group 1 ratio >3 (n=52) and Group 2 ratio ≤3(n=43)]. Hemoglobin (p=0.035) and albumin levels (p=0.004) were lower in the Group 1. When the stage increased, differences between the rectal cancer groups were found. Overall survival was significantly lower in the Group 1 (p=0.013). Conclusions The study showed that a high neutrophil-lymphocyte ratio had an adverse effect on overall survival in colorectal cancer patients who had a curative surgery. However, we could not establish any association between neutrophil-lymphocyte ratio and the factors such lymphovascular invasion, perineural invasion, tumor size expect hemoglobin and serum albumin levels. |
| Databáze: | OpenAIRE |
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