Association study of polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with susceptibility and prognosis of heart failure
| Autor: | Vanessa Laubert La Porta, Kátia Gonçalves dos Santos, Nadine Oliveira Clausell, Andreia Biolo, Luis Eduardo Paim Rohde, Carolina Rodrigues Cohen, Vanessa Backes Nascimento Diel |
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| Rok vydání: | 2012 |
| Předmět: |
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medicine.medical_specialty Genotype Receptor for Advanced Glycation End Products Black People Kaplan-Meier Estimate Biology Gastroenterology Polymorphism Single Nucleotide Linkage Disequilibrium White People Gene Frequency Receptor for advanced glycation end-products (RAGE) Glycation Internal medicine Diabetes mellitus Genetics medicine Humans Genetic Predisposition to Disease Allele Receptors Immunologic Genotyping Survival analysis Alleles Aged Heart Failure Diabetes Haplotype General Medicine Middle Aged medicine.disease Prognosis Endocrinology Haplotypes Heart failure Female Polymorphisms Brazil |
| Zdroj: | Gene. 510(1) |
| ISSN: | 1879-0038 |
| Popis: | Background Functional polymorphisms in the receptor for advanced glycation end-products ( RAGE ) gene have been implicated in several vascular diseases. However, to date, no study investigated the association of RAGE polymorphisms with heart failure (HF). Objective In this study we tested the hypothesis that the 63-bp insertion/deletion, the − 374T > A (rs1800624) and the − 429T > C (rs1800625) polymorphisms in the RAGE gene might be associated with susceptibility to HF and could predict all-cause mortality in Brazilian outpatients with left ventricular systolic dysfunction. Methods A total of 273 consecutive HF patients (196 Caucasian- and 77 African-Brazilians) and 334 healthy blood donors (260 Caucasian- and 74 African-Brazilians) were enrolled in a tertiary care university hospital. Genotyping of RAGE polymorphisms was done by polymerase chain reaction (PCR) or PCR followed by enzyme restriction analysis. Results The allele, genotype and haplotype frequencies of − 374T > A and − 429T > C polymorphisms were not significantly different between HF patients and healthy blood donors in both ethnic groups. However, among African-Brazilians, the frequency of carriership of the del allele was lower in HF patients than in blood donors (2.6% vs 12.2%, respectively, p = 0.008). Patients were followed-up for a median of 38 months and the survival analysis did not reveal a consistent association between RAGE polymorphisms and all-cause death in both ethnic groups. Conclusion The − 374T > A and − 429T > C polymorphisms in the RAGE gene were not associated with the susceptibility and prognosis of HF. Notwithstanding, the 63-bp ins/del polymorphism might be involved in the susceptibility to HF in African-Brazilians. |
| Databáze: | OpenAIRE |
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