Pediatric Bipolar Disorder Versus Severe Mood Dysregulation: Risk for Manic Episodes on Follow-Up
| Autor: | Melissa A. Brotman, Reilly R. Kayser, Caroline Haimm, Kenneth E. Towbin, Ellen Leibenluft, Frances S. Myers, Argyris Stringaris, Eileen Rustgi, Wanda Wheeler, Catherine H. Lowe, Argelinda Baroni |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty Disruptive mood dysregulation disorder Irritability medicine.disease Confidence interval Psychiatry and Mental health Mood El Niño mental disorders Developmental and Educational Psychology medicine Bipolar disorder medicine.symptom Risk factor Psychology Psychiatry Mania |
| Zdroj: | Stringaris, A, Baroni, A, Haimm, C, Brotman, M, Lowe, C H, Myers, F, Rustgi, E, Wheeler, W, Kayser, R, Towbin, K & Leibenluft, E 2010, ' Pediatric Bipolar Disorder Versus Severe Mood Dysregulation: Risk for Manic Episodes on Follow-Up ', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 49, no. 4, pp. 397-405 . https://doi.org/10.1016/j.jaac.2010.01.013 |
| ISSN: | 0890-8567 |
| DOI: | 10.1016/j.jaac.2010.01.013 |
| Popis: | ObjectiveAn important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be significantly less likely to develop (hypo-)manic or mixed episodes over time than will youth with bipolar disorder (BD).MethodPatients with SMD (N = 84) and narrowly defined BD (N = 93) at baseline were followed up in 6-monthly intervals using the relevant K-SADS modules to ascertain (hypo-)manic or mixed episodes.ResultsOnly one of 84 SMD subjects (1/84 [1.2%]; 95% confidence interval CI = 0.0003 to 0.064) experienced a (hypo-)manic or mixed episode during the study (median follow-up = 28.7 months). The frequency of such episodes was more than 50 times higher in those with narrowly defined BD (58/93 [62.4%]; 95% CI 0.52 to 0.72).ConclusionsThese data suggest that, over an approximately 2-year follow-up period, youth with SMD are unlikely to develop (hypo-)manic or mixed episodes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|