A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila
| Autor: | Lisa-Marie Frisch, Ilona C. Grunwald Kadow, Marta Costa, Laurence P. Lewis, Corey B. Fisher, Jean-Francois De Backer, K.P. Siju, Gregory S.X.E. Jefferis, Sercan Sayin, Benedikt Gansen, Philipp Schlegel, Julijana Gjorgjieva, J. Scott Lauritzen, Nadiya Sharifi, Marina E. Wosniack, Davi D. Bock, Amelia J. Edmondson-Stait, Steven A. Calle-Schuler |
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| Přispěvatelé: | Apollo-University Of Cambridge Repository, Jefferis, Gregory [0000-0002-0587-9355], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Persistence (psychology) Olfactory system Hunger olfactory system 0302 clinical medicine ddc:590 octopamine Neural Pathways Drosophila Proteins Attention Neurons Appetitive Behavior learning Behavior Animal General Neuroscience Dopaminergic persistence ddc Smell medicine.anatomical_structure Drosophila melanogaster Memory Short-Term Mushroom bodies Drosophila dopamine Olfaction Biology Article foraging 03 medical and health sciences Reward ddc:570 medicine Animals goal-directed behavior Mushroom Bodies Motivation Receptors Dopamine D1 Dopaminergic Neurons biology.organism_classification mushroom body 030104 developmental biology Odor Food Odorants goal-directed behavior olfactory system dopamine mushroom body Drosophila melanogaster octopamine persistence foraging DopR2 learning Neuron DopR2 Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| ISSN: | 1097-4199 0896-6273 |
| Popis: | Summary In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive. Graphical Abstract Highlights • Hunger motivates persistent food odor tracking even without reward • Two synaptically connected MBONs, -γ1pedc>αβ and -α2sc, regulate odor tracking • Octopamine neurons connect feeding and counteract MBON and odor tracking • Dopaminergic neurons and Dop1R2 signaling promote persistent tracking What drives behavioral persistence versus quitting? Sayin et al. propose that circuit modules in the fly’s learning center and dopamine drive gradually increasing food odor tracking, which can be efficiently suppressed by extrinsic, but directly innervating, feeding-related neuromodulatory neurons. |
| Databáze: | OpenAIRE |
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