Behavioral effects evoked by SKF 38393 and LY 171555 in adult cats
| Autor: | E. Motles, Ariel Gomez, Montserrat Tetas |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Agonist
medicine.medical_specialty Quinpirole Apomorphine medicine.drug_class Emotions Experimental and Cognitive Psychology Motor Activity Pharmacology Dopamine agonist Behavioral Neuroscience chemistry.chemical_compound Internal medicine Dopamine receptor D2 medicine Animals Ergolines Neurotransmitter CATS Behavior Animal Dose-Response Relationship Drug Receptors Dopamine D2 Receptors Dopamine D1 Dopaminergic Brain Endocrinology chemistry Dopamine Agonists Cats Excitatory postsynaptic potential 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Stereotyped Behavior Arousal Psychology medicine.drug |
| Zdroj: | Physiology & Behavior. 57:983-988 |
| ISSN: | 0031-9384 |
| Popis: | The aim of the present work was to study the behavioral effects elicited in adult cats by the selective D1 agonist, SKF 38393, and the D2 agonist, LY 171555, comparing their effects with those evoked by apomorphine. In 10 adult cats, 0.5, 1.0, 4.0, and 8.0 mg/kg IP of SKF 38393 were administered at random. A dose-response effect was observed related to alertness, indifference, and locomotion. The overall effect of SKF 38393 was inhibitory. To the same 10 animals, LY 171555 in doses of 0.25, 0.5, and 1.0 mg/kg were injected IP. This drug had an excitatory and more complex effect than what was observed with the D1 agonist. Increases in locomotion, in alertness, indifference, fear, olfaction, pupillary dilation, hallucination, limb flicking, and head shaking were recorded. Apomorphine given to the same cats, in a dose equimolar to 1.0 mg/kg of LY 171555, elicited behaviors that resembled those elicited by the latter drug, but of a lesser intensity and duration. The interval between the different treatments was approximately 2 months. These results show clearly that the D2 receptor is the main dopaminergic receptor involved in the mechanism of production of most of the behavioral effects produced by some of the dopaminergic agonist drugs like apomorphine. |
| Databáze: | OpenAIRE |
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