Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin
| Autor: | Liu Wei, Jingyi Zhang, Hua He, Pierre Dramou, Abdoh Taleb, Asma Itatahine, Yamina Ait Mehdi, Meriem Fizir, Nasiru Sintali Dahiru |
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| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
Cell Survival Oligosaccharides Antineoplastic Agents 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences Chitosan chemistry.chemical_compound Structure-Activity Relationship Drug Delivery Systems Folic Acid Materials Chemistry medicine Tumor Cells Cultured Humans Cell Proliferation Nanotubes Dose-Response Relationship Drug Chemistry Cell growth Organic Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Cancer cell Drug delivery Biophysics Camptothecin Nanocarriers Drug Screening Assays Antitumor 0210 nano-technology Intracellular medicine.drug |
| Zdroj: | Carbohydrate polymers. 197 |
| ISSN: | 1879-1344 |
| Popis: | In this research, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemotherapy, folic acid conjugated chitosan oligosaccharides assembled magnetic halloysite nanotubes (FA-COS/MHNTs) have been tailored as multitask drug delivery system towards camptothecin (CPT). Besides magnetic targeting, the nanocomposites have been reacted with folate complex in order to selectively target cancer cells over expressing the folic acid receptor. HNTs showed to have a high storage capacity of CPT. In vitro, the release results indicated that CPT outflow from the nanocarriers at pH 5 was much greater than that at both pH 6.8 and 7.4. MTT assays showed that the CPT-loaded nanocarriers exhibited stronger cell growth inhibitory against colon cancer cell. Furthermore, nanocarriers gained specificity to target cancer cells because of the enhanced cell uptake mediated by FA moiety and presence of COS. Therefore, the rational designed HNTs nanocarrier for chemotherapy drug showed great potential as tumor-targeted drug delivery carrier. |
| Databáze: | OpenAIRE |
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