Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics
| Autor: | Shwetadwip Chowdhury, Adam Wax, Francisco E. Robles |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Absorption (pharmacology)
Pathology medicine.medical_specialty Materials science Absorption spectroscopy Diffuse reflectance infrared fourier transform 02 engineering and technology 01 natural sciences 010309 optics Nuclear magnetic resonance ocis:(170.6510) Spectroscopy tissue diagnostics Optical coherence tomography 0103 physical sciences medicine ocis:(300.1030) Absorption medicine.diagnostic_test ocis:(110.4500) Optical coherence tomography 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics ocis:(170.1470) Blood or tissue constituent monitoring Attenuation coefficient Hemoglobin 0210 nano-technology Biological imaging Spectroscopic Diagnostics Biotechnology |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.1.000310 |
| Popis: | Hemoglobin (Hb) concentration and oxygen saturation levels are important biomarkers for various diseases, including cancer. Here, we investigate the ability to measure these parameters for tissue using spectroscopic optical coherence tomography (SOCT). A parallel frequency domain OCT system is used with detection spanning the visible region of the spectrum (450 nm to 700 nm). Oxygenated and deoxygenated Hb absorbing phantoms are analyzed. The results show that Hb concentrations as low as 1.2 g/L at 1 mm can be retrieved indicating that both normal and cancerous tissue measurements may be obtained. However, measurement of oxygen saturation levels may not be achieved with this approach. |
| Databáze: | OpenAIRE |
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