Cyclin D1 (CCND1) G870A polymorphisms and cervical cancer susceptibility: a Meta-analysis based on Ten case–control studies
Autor: | Hanbin Zhang, Haohai Huang, Yongfu Wu, Huiling Yang, Li Zhang, Dongyun Qin, Hui Fu, Miao Chen |
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Rok vydání: | 2014 |
Předmět: |
Oncology
medicine.medical_specialty Uterine Cervical Neoplasms Subgroup analysis Bioinformatics Polymorphism Single Nucleotide White People Asian People Risk Factors Internal medicine Genotype Genetic predisposition Humans Medicine Cyclin D1 Genetic Predisposition to Disease Allele Genetic Association Studies Cervical cancer business.industry Case-control study General Medicine Odds ratio medicine.disease Case-Control Studies Meta-analysis Female business |
Zdroj: | Tumor Biology. 35:6913-6918 |
ISSN: | 1423-0380 1010-4283 |
DOI: | 10.1007/s13277-014-1929-6 |
Popis: | Many studies have evaluated the association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer susceptibility. However, these studies showed inconsistent results. The aim of this study was to derive a more precise estimation of this association. We searched PubMed and Embase for related studies that had been published in English, and ten case-control studies with a total of 2,864 cases and 3,898 controls were finally identified to be eligible studies in the meta-analysis. The association was assessed by summarizing the odds ratios (ORs) with the corresponding 95 % confidence intervals (CIs). Overall, there was no significant association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer risk (for the allele model A vs. G: OR = 1.02, 95 % CI 0.88-1.19, p = 0.76; for the co-dominant model AA vs. GG: OR = 1.03, 95 % CI 0.75-1.41, p = 0.85; for the dominant model AA + GA vs. GG: OR = 1.00, 95 % CI 0.78-1.28, p = 0.99; for the recessive comparison AA vs. GA + GG: OR = 1.06, 95 % CI 0.85-1.32, p = 0.62). In subgroup analysis by ethnicity, no significant difference was found in both Asians and Caucasians. In summary, the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer. |
Databáze: | OpenAIRE |
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