Effect of Atrial Natriuretic Peptide on Sodium-Glucose Cotransport in the Rat Small Intestine
| Autor: | L.V. González Bosc, P. A. Elustondo, N.A. Vidal, M.C. Ortiz |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Patch-Clamp Techniques Monosaccharide Transport Proteins Physiology medicine.drug_class Voltage clamp Sodium chemistry.chemical_element Nitric Oxide Biochemistry Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Atrial natriuretic peptide Internal medicine Intestine Small medicine Natriuretic peptide Animals Rats Wistar Cyclic GMP Ion transporter Electric Conductivity Biological Transport Small intestine Rats Methylene Blue Phlorhizin medicine.anatomical_structure chemistry cardiovascular system Cotransporter Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 18:1491-1495 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(97)00240-4 |
| Popis: | GonzALez Bosc, L. V., P. A. Elustondo, M. C. Ortiz and N. A. Vidal. Effect of atrial natriuretic peptide on sodium-glucose cotransport in the rat small intestine. Peptides 18(10) 1491–1495, 1997.—Atrial natriuretic peptide (ANP) decreases sodium absorption in small intestine of rats in vitro under sodium concentration-gradient conditions (SCG) and this effect may be mediated by the inhibition of the sodium/glucose cotransporter (SGLT). In order to assess this hypothesis, the effects of ANP, phloridzine (Phlz) and methylene blue (MB), added alone or together, using a voltage clamp technique in Ussing’s chamber with SCG were studied. ANP and Phlz significantly decreased potential difference and short circuit current. Effects of Phlz and ANP were not additive. The addition of MB alone did not affect ion transport, whereas it abolished ANP effects. These data suggest that ANP blocks the SGLT through mechanisms mediated by cGMP and/or NO. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect