Therapeutic implications of iodine-125 cytotoxicity
| Autor: | Stephen Adelstein, W. H. McLaughlin, William D. Bloomer |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cancer Research
Cell Survival chemistry.chemical_element Estrogen receptor Iodine Cell Line Iodine Radioisotopes Mice chemistry.chemical_compound Cricetulus Cricetinae Idoxuridine Neoplasms medicine Animals Humans Radiology Nuclear Medicine and imaging Cytotoxicity Radiation business.industry Intercalating Agents Tamoxifen Cell killing Oncology chemistry Cancer management Cancer research business Nuclear medicine DNA medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 8:1903-1908 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(82)90448-5 |
| Popis: | The biological consequences of differential subcellular radionuclide accumulation within nuclear structures have important implications for the design and development of new therapeutic agents for cancer management. A growing body of experimental data demonstrates that localization of 125 I within the genome results in marked cytotoxicity. Investigations of iodine-125 labeled iododeoxyuridine, DNA intercalators and tamoxifen are reviewed as representative of this new group of potential radiotherapeutic agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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