IS RESISTIN A LINK BETWEEN HIGHLY ACTIVE ANTIRETROVIRAL THERAPY AND FAT REDISTRIBUTION IN HIV-INFECTED CHILDREN?
| Autor: | Raffaele Iorio, Monica Volpicelli, Eugenia Bruzzese, Annunziata Officioso, Maria Immacolata Spagnuolo, G. De Marco, A. Franzese, N. Fasano, Gianfranco Vallone, Alfredo Guarino, Giuliana Valerio |
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| Přispěvatelé: | Spagnuolo, MARIA IMMACOLATA, Bruzzese, Eugenia, Vallone, Gianfranco, Fasano, N, De Marco, G, Officioso, Annunziata, Valerio, G, Volpicelli, M, Iorio, Raffaele, Guarino, Alfredo |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty HAART Adolescent Lipodystrophy Endocrinology Diabetes and Metabolism Antiretroviral Therapy Adipose tissue Blood lipids HIV Infections Endocrinology Insulin resistance Antiretroviral Therapy Highly Active Internal medicine medicine Animals Body Fat Distribution Humans Highly Active Resistin Visceral fat Child Children Anthropometry business.industry HIV HIV Protease Inhibitors medicine.disease Adipose Tissue Fat redistribution business Homeostasis Hormone |
| Zdroj: | Scopus-Elsevier |
| Popis: | OBJECTIVES: To assess the features of fat redistribution, detected by clinical and ultrasound (US) methods, and the presence of metabolic disorders in HIV-infected children undergoing antiretroviral therapy. To evaluate if serum levels of resistin, a hormone produced only by visceral adipose tissue, are a marker of fat redistribution in these patients. DESIGN AND METHODS: Forty-five consecutive symptomatic HIV-infected children were considered for inclusion in the study. Patients were enrolled if treated for at least 6 months with antiretroviral therapy with or without protease inhibitor (PI) and if compliant to the study protocol. Patients were evaluated for: anthropometric measures, fat redistribution by clinical and US methods, serum lipids, parameters of insulin resistance by homeostasis model assessment for insulin resistance, serum resistin levels by an enzyme-linked immunosorbent assay. RESULTS: Eighteen children fulfilled the inclusion criteria and were enrolled in the study. Twelve (66%) children had clinical and/or US evidence of fat redistribution; 9 (75%) of them were on PI therapy; only 3 of 6 children without fat redistribution were on PI therapy (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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