Treatment of Neuroblastoma with a Novel Delayed Intensification Chemotherapy
| Autor: | Zi‐ling Liu, Yu-Tong Zhang, Xiao-dan Zhong, Ya‐nan Li, Jian Chang, Hong-Mei Xu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Oncology China medicine.medical_specialty Vincristine Drug-Related Side Effects and Adverse Reactions Cyclophosphamide medicine.medical_treatment Disease-Free Survival Neuroblastoma 03 medical and health sciences 0302 clinical medicine Drug Therapy Positron Emission Tomography Computed Tomography 030225 pediatrics Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Doxorubicin Child Etoposide Cisplatin Chemotherapy business.industry Infant medicine.disease Survival Rate Regimen Child Preschool Pediatrics Perinatology and Child Health Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Indian Journal of Pediatrics. 86:126-131 |
| ISSN: | 0973-7693 0019-5456 |
| DOI: | 10.1007/s12098-018-2737-6 |
| Popis: | To test the feasibility of adding a novel delayed intensification chemotherapy to a dose-intensive induction regimen chemotherapy for high-risk neuroblastoma. Patients enrolled in this study received chemotherapy in accordance with the design of the NB97 trial. At the end of the therapy, patients received three cycles of delayed intensification chemotherapy. The delayed intensification chemotherapy consists of two A1 and one A2 cycle. The A1 cycle consists of 1.5 mg/m2 of vincristine on day 1, 1.2 g/m2 of cyclophosphamide on day 2, 100 mg/m2 of cisplatin on day 3, and 160 mg/m2 of etoposide on day 4. The A2 cycle is similar to the A1 cycle, however the only difference is that on day 4, 30 mg/m2 of doxorubicin is substituted for etoposide. Between 2007 to 2011, a total of thirty-six patients were enrolled, sixteen patients were long term event-free survivors. Three patients were alive with tumor whilst fifteen patients died. The 3-year Event free survival (EFS) and Overall survival (OS) were 44.4% (95%CI, 27.4 to 61.5%) and 50% (95%CI, 32.8 to 67.2%) respectively. A high rate of survival among patients with high-risk neuroblastoma was achieved with delayed intensification chemotherapy without the occurrence of a second malignancy. |
| Databáze: | OpenAIRE |
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