Thiol homeostasis and supplements in physical exercise
| Autor: | Lester Packer, Chandan K. Sen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Cell signaling Antioxidant Adolescent Riboflavin medicine.medical_treatment Medicine (miscellaneous) medicine.disease_cause Gene Expression Regulation Enzymologic Mice Selenium chemistry.chemical_compound Dogs medicine Animals Homeostasis Humans Sulfhydryl Compounds Muscle Skeletal Exercise Aged chemistry.chemical_classification Nutrition and Dietetics Thioctic Acid Age Factors Glutathione Metabolism Middle Aged Acetylcysteine Rats Oxidative Stress Lipoic acid chemistry Biochemistry Dietary Supplements Thiol Female Oxidative stress Signal Transduction Cysteine |
| Zdroj: | The American Journal of Clinical Nutrition. 72:653S-669S |
| ISSN: | 0002-9165 |
| Popis: | Thiols are a class of organic sulfur derivatives (mercaptans) characterized by the presence of sulfhydryl residues. In biological systems, thiols have numerous functions, including a central role in coordinating the antioxidant defense network. Physical exercise may induce oxidative stress. In humans, a consistent marker of exercise-induced oxidative stress is blood glutathione oxidation. Physical training programs have specific effects on tissue glutathione metabolism that depend on the work program and the type of tissue. Experimental studies show that glutathione metabolism in several tissues sensitively responds to an exhaustive bout of exercise. Study of glutathione-deficient animals clearly indicates the central importance of having adequate tissue glutathione to protect against exercise-induced oxidative stress. Among the various thiol supplements studied, N-acetyl-L-cysteine and alpha-lipoic acid hold the most promise. These agents may have antioxidant effects at the biochemical level but are also known to influence redox-sensitive cell signaling. |
| Databáze: | OpenAIRE |
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