Synthesis and cytogenetic studies of structure–biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with ,-bis(2-chloroethyl)aminocinnamic acid isomers
| Autor: | E. Mioglou, Chariclia Gasparinatou, George Pairas, Z. Iakovidou, Dionysios Mourelatos, Charalabos Camoutsis |
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| Rok vydání: | 2005 |
| Předmět: |
Sapogenins
Stereochemistry medicine.medical_treatment Clinical Biochemistry Cinnamic acid ester Biochemistry Cinnamic acid Steroid Structure-Activity Relationship chemistry.chemical_compound Endocrinology Isomerism Biosynthesis Proliferation rate medicine Humans Lymphocytes neoplasms Molecular Biology Cell Proliferation Pharmacology Aza Compounds Esterification Molecular Structure Mutagenicity Tests organic chemicals Organic Chemistry Biological activity Antineoplastic Agents Phytogenic chemistry Cinnamates Nitrogen Mustard Compounds Sister Chromatid Exchange |
| Zdroj: | Steroids. 70:586-593 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/j.steroids.2005.02.018 |
| Popis: | The esters of Hecogenin and aza-homo-Hecogenin with N , N -bis(2-chloroethyl)aminocinnamic acid isomers have been prepared and their cytogenetic studies of structure–biological activity relationship were evaluated. The cytogenetic effects (sister chromatid exchages (SCEs) induction and proliferation rate indices (PRIs) depression) by o -, m - and p -[ N , N -bis(2-chloroethyl)amino] cinnamic acid were also investigated. Among the above compounds tested, those of the m -[ N , N -bis(2-chloroethyl)amino] cinnamic acid and of the o -[ N , N -bis(2-chloroethyl)amino] cinnamic acid ester of aza-homo-Hecogenin were more active in comparison to the others. |
| Databáze: | OpenAIRE |
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