Self-Sampling for Human Papillomavirus Testing: Increased Cervical Cancer Screening Participation and Incorporation in International Screening Programs
| Autor: | Sarah Gupta, Christina Palmer, Elisabeth M. Bik, Juan P. Cardenas, Harold Nuñez, Laurens Kraal, Sara W. Bird, Jennie Bowers, Alison Smith, Nathaniel A. Walton, Audrey D. Goddard, Daniel E. Almonacid, Susan Zneimer, Jessica Richman, Zachary S. Apte |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
cervical cancer Review Cervical cancer screening 03 medical and health sciences 0302 clinical medicine Cancer screening medicine 030212 general & internal medicine Human papillomavirus human papillomavirus Socioeconomic status Cervical cancer Obstetrics business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health HPV infection self-sampling vaginal microbiome lcsh:RA1-1270 Nucleic acid amplification technique medicine.disease female genital diseases and pregnancy complications cancer screening 030220 oncology & carcinogenesis Public Health business Developed country |
| Zdroj: | Frontiers in Public Health Frontiers in Public Health, Vol 6 (2018) |
| ISSN: | 2296-2565 |
| Popis: | In most industrialized countries, screening programs for cervical cancer have shifted from cytology (Pap smear or ThinPrep) alone on clinician-obtained samples to the addition of screening for human papillomavirus (HPV), its main causative agent. For HPV testing, self-sampling instead of clinician-sampling has proven to be equally accurate, in particular for assays that use nucleic acid amplification techniques. In addition, HPV testing of self-collected samples in combination with a follow-up Pap smear in case of a positive result is more effective in detecting precancerous lesions than a Pap smear alone. Self-sampling for HPV testing has already been adopted by some countries, while others have started trials to evaluate its incorporation into national cervical cancer screening programs. Self-sampling may result in more individuals willing to participate in cervical cancer screening, because it removes many of the barriers that prevent women, especially those in low socioeconomic and minority populations, from participating in regular screening programs. Several studies have shown that the majority of women who have been underscreened but who tested HPV-positive in a self-obtained sample will visit a clinic for follow-up diagnosis and management. In addition, a self-collected sample can also be used for vaginal microbiome analysis, which can provide additional information about HPV infection persistence as well as vaginal health in general. |
| Databáze: | OpenAIRE |
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