Frequency and prognosis of metastasis to liver, lung, bone and brain from Merkel cell carcinoma
| Autor: | YiJun Xia, BangZhong Zhu, Dong Sheng Cao, Jun Zhao, Juan Xie |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Skin Neoplasms Databases Factual medicine.medical_treatment Sentinel lymph node Bone Neoplasms Metastasis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Humans Prospective cohort study Survival rate Lymph node Aged Retrospective Studies Aged 80 and over Chemotherapy medicine.diagnostic_test Brain Neoplasms business.industry Merkel cell carcinoma Liver Neoplasms food and beverages General Medicine Middle Aged Prognosis medicine.disease Combined Modality Therapy Carcinoma Merkel Cell Survival Rate medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Female business |
| Zdroj: | Future Oncology. 16:1101-1113 |
| ISSN: | 1744-8301 1479-6694 |
| Popis: | Aim: To describe the factors affecting distant metastasis of Merkel cell carcinoma (MCC) and the prognosis of metastatic MCC. Materials & methods: The MCC patient information was downloaded from the SEER database. Logistic regression and Cox proportional hazard models were conducted to screen for significant factors. Results: A total of 3449 patients were enrolled. Surgery and chemotherapy were significantly correlated with the occurrence of distant metastasis. In the cause-specific survival rate of MCC, regional lymph node removal, sentinel lymph node biopsy, radiation and chemotherapy can significantly reduce the prognostic risk of patients with distant metastases. Conclusion: Our study screened out the factors affecting the distant metastasis and prognosis of MCC and more prospective studies are needed to verify our findings. |
| Databáze: | OpenAIRE |
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