Threshold responses in formaldehyde-sensitive subjects
| Autor: | Sarah E. King, William T. Sherman, William P. Jordan |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Clinical Trials as Topic
medicine.medical_specialty Preservative FORMALDEHYDE SOLUTION Chromatography business.industry Parts-per notation Formaldehyde Patch test Drug Tolerance Dermatology Patch Tests Surgery Ointments chemistry.chemical_compound Double-Blind Method chemistry medicine Humans Hypersensitivity Delayed business Normal skin Volume concentration Skin Tests |
| Zdroj: | Journal of the American Academy of Dermatology. 1:44-48 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/s0190-9622(79)70003-x |
| Popis: | Patch tests with three low concentrations of formaldehyde were applied continuously in formaldehyde-sensitive subjects for 1 wk. The closed patch test method produced a response to 30 parts per million (ppm) in some subjects by 120 continuous hours of testing. Thirteen subjects then sprayed a 30-ppm formaldehyde solution in an axilla on a double-blind, controlled, 2-wk-use test. Their responses to 30 ppm aqueous formaldehyde indicate that levels below this concentration should be tolerated by sensitive subjects if repeatedly applied to normal skin. Popular formaldehyde-releasing preservatives can be above or below this threshold-eliciting response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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