Repetitive Transcranial Magnetic Stimulation Delivered With an H-Coil to the Right Insula Reduces Functional Connectivity Between Insula and Medial Prefrontal Cortex
| Autor: | Mary R. Lee, Karen McCullough, Betty Jo Salmeron, Andrea M. Maxwell, Elisabeth C. Caparelli, Vaughn R. Steele, Michelle K. Leff |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Elementary cognitive task medicine.medical_treatment Prefrontal Cortex Pilot Projects Audiology behavioral disciplines and activities Young Adult 03 medical and health sciences 0302 clinical medicine Neural Pathways mental disorders Neuroplasticity medicine Humans Prefrontal cortex Anterior cingulate cortex Cerebral Cortex Resting state fMRI medicine.diagnostic_test business.industry General Medicine Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation Anesthesiology and Pain Medicine medicine.anatomical_structure nervous system Neurology Female Neurology (clinical) Functional magnetic resonance imaging business Insula psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Neuromodulation: Technology at the Neural Interface. 23:384-392 |
| ISSN: | 1094-7159 |
| Popis: | OBJECTIVE Insula neurocircuitry alterations are reported in a range of neuropsychiatric disorders holding promise for clinical interventions. We measured, in a pilot study, acute neuroplastic modulations resulting from high- and low-frequency stimulation with repetitive transcranial magnetic stimulation (rTMS) delivered via an H-coil that targeted the right insula and overlying prefrontal cortex. METHODS Healthy, nonsmoking, adult participants (N = 28), in a within-participant, sham-controlled experiment, received a single rTMS session on four separate days. Participants received one session each of low- (1 Hz) and high (10 Hz)-frequency stimulation and two sessions of sham stimulation matched to each rTMS frequency. After each rTMS session, participants completed a functional magnetic resonance imaging (fMRI) scan while performing two cognitive tasks and a resting-state scan. The effect of rTMS was examined on task behavior as well as blood oxygenated level-dependent (BOLD) response during task performance and resting state. We expected low- and high-frequency stimulation to decrease and increase, respectively, insula and overlying cortical BOLD signal and network connectivity. RESULTS/CONCLUSIONS There was no effect of rTMS, regardless of frequency, on task behavior or task-based BOLD response. There was an effect of rTMS compared to sham on rsFC between insula and medial prefrontal cortex, with connectivity reduced after rTMS compared to sham, regardless of frequency. Implications for using rTMS to the insula as a treatment for neuropsychiatric disorders are discussed in light of insula-medial prefrontal cortex connectivity. |
| Databáze: | OpenAIRE |
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