Erythrocyte Alloimmunity and Genetic Variance: Results from the Collaborative Study of Alloimmunity to Antigen Diversity in Asian Populations (All ADP)
Autor: | Kinuyo Kawabata, Attapong Sinkitjasub, Chiaki Yamada, Chan Pui Ha Natalie, Hitoshi Ohto, Naoki Ohtomo, V. S. Nadarajan, Jang Soo Suh, Hyun Ok Kim, Shuming Zhao, Kimiko Yurugi, Kyou Sup Han, Dae Won Kim, Ken Ishimaru, Hiroko Watanabe, Yutaka Tomoda, Akihiro Takeshita, Naotomo Yamada, Parichart Permpikul |
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Rok vydání: | 2020 |
Předmět: |
Male
Pregnancy Erythrocytes Alloimmunity Genetic Variation Hematology 030204 cardiovascular system & hematology Biology medicine.disease 03 medical and health sciences 0302 clinical medicine Asian People Antigen Isoantibodies Immunology Genetic variation biology.protein medicine Humans Female Antibody 030215 immunology |
Zdroj: | Transfusion and Apheresis Science. 59:102944 |
ISSN: | 1473-0502 |
DOI: | 10.1016/j.transci.2020.102944 |
Popis: | As an East-Asian international study, we evaluated erythrocyte alloimmunity by gender and history of transfusion or pregnancy. In total, data from more than 1,826,000 patients were analyzed, from whom 26,170 irregular erythrocyte antibodies were detected in 22,653 cases. Antibody frequencies in these cases were as follows: anti-E, 26.8%; anti-Lea, 20.0%; anti-P1, 7.1%; anti-M, 6.4%; anti-Mia, 5.6%; anti-c + E, 5.6%; anti-Leb, 4.6%; anti-D, 2.8%; anti-Fyb, 2.6%; anti-Lea+Leb, 2.5%; anti-Dia, 2.0%; and others. For pregnant patients, anti-D (12.7%) was statistically more frequent. For transfused patients, anti-E (37.3%), anti-c + E (9.5%), anti-C + e (3.3%) and anti-Jka (3.1%) were significantly more frequent. |
Databáze: | OpenAIRE |
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