PSA mass as a marker of prostate cancer progression after radical prostatectomy
| Autor: | Andrzej Paradysz, Piotr Bryniarski, Mieczysław Fryczkowski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Biochemical recurrence
Male medicine.medical_specialty obesity medicine.medical_treatment Urology Kaplan-Meier Estimate urologic and male genital diseases Body Mass Index Prostate cancer Clinical Research Predictive Value of Tests Recurrence Biomarkers Tumor Odds Ratio Medicine Humans Aged Prostatectomy Receiver operating characteristic business.industry Prostatic Neoplasms General Medicine PSA mass Middle Aged Prostate-Specific Antigen medicine.disease prostate cancer radical prostatectomy Log-rank test Molecular Weight Prostate-specific antigen Logistic Models ROC Curve Predictive value of tests hemodilution Disease Progression business Body mass index |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | Summary Background Obese patients with prostate cancer may have lower preoperative PSA concentration due to hemodilution. Lower PSA concentration may falsely affect assessing the risk of progression after radical prostatectomy (RP). The aim of this study was to determine preoperative PSA mass as the absolute amount of PSA protein secreted into circulation, and evaluation of its usefulness in prediction of biochemical recurrence after RP. Material/Methods 177 patients after RP due to prostate cancer were included in the study. On the basis of formulas, PSA mass was calculated {PSA mass [μg] = (weight [kg])0.425 × (height [cm])0.72 × 0.007184 × 1.670 × PSA concentration [ng/ml]}. Patients were divided into 3 groups according to increasing values of PSA mass. The following features were assessed and compared between these groups (χ-square test): pathologic stage T3, nodal metastases, positive surgical margins, biochemical and local recurrence and the rate of death. Cancer-specific survival was assessed depending on PSA mass (Kaplan-Meier curves with log rank test). The usefulness of PSA mass in prediction of biochemical recurrence was compared with PSA concentration (logistic regression with ROC curves). Results Pathologic stage T3, nodal metastases, positive surgical margins and progression were more common in patients with higher levels of PSA mass (p |
| Databáze: | OpenAIRE |
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