Whole inactivated SIV vaccine grown on human cells fails to protect against homologous SIV grown on simian cells
| Autor: | Martin Cranage, Per Putkonen, Anne Marie Aubertin, Gunnel Biberfeld, Charlotta Nilsson, Reinhold Benthin, Kerstin Hild |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Virus Cultivation
animal diseases viruses Retroviridae Proteins Oncogenic Simian Acquired Immunodeficiency Syndrome Simian medicine.disease_cause Macaque Virus Cell Line Species Specificity biology.animal medicine Animals Humans AIDS Vaccines General Veterinary biology Viral Vaccine Gene Products env virus diseases Viral Vaccines Simian immunodeficiency virus biology.organism_classification Virology Disease Models Animal Macaca fascicularis Vaccines Inactivated Immunization Cell culture Simian Immunodeficiency Virus Animal Science and Zoology Viral Fusion Proteins |
| Zdroj: | Journal of Medical Primatology. 22:100-103 |
| ISSN: | 1600-0684 0047-2565 |
| DOI: | 10.1111/j.1600-0684.1993.tb00646.x |
| Popis: | Several groups have reported protection against experimental SIV infection in macaques immunized with a whole inactivated virus vaccine. The aim of the current study was to investigate whether five macaques vaccinated with whole inactivated SIV and previously shown to be protected against challenge with two divergent strains of SIV grown on human cells could resist challenge with a subsequent homologous SIV grown on macaque cells. We show here that this same vaccine did not protect when the challenge virus was grown on primary cells of monkey origin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|