Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits
| Autor: | Dirk J.A. Smit, Wim van den Brink, Michel G. Nivard, Karin J. H. Verweij, Eske M. Derks, Titus Galama, Andries T. Marees, Damiaan Denys, Abdel Abdellaoui |
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| Přispěvatelé: | Economics, Biological Psychology, Tinbergen Institute, Applied Economics, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, APH - Mental Health, ANS - Complex Trait Genetics |
| Rok vydání: | 2020 |
| Předmět: |
Obsessive-Compulsive Disorder
Anorexia Nervosa Bipolar Disorder Schizophrenia/genetics Autism Spectrum Disorder Smoking/genetics Behavioral Neuroscience 0302 clinical medicine Models Anorexia Nervosa/genetics Epidemiology Substance-Related Disorders/genetics Obsessive-Compulsive Disorder/genetics 0303 health sciences Mental Disorders Bipolar Disorder/genetics Smoking Major/genetics Single Nucleotide Anxiety Disorders 3. Good health Mental Health Latent Class Analysis Income Educational Status Attention Deficit Disorder with Hyperactivity/genetics Depressive Disorder Major/genetics Psychology medicine.medical_specialty Social Psychology Alcohol Drinking Substance-Related Disorders Experimental and Cognitive Psychology Biology Polymorphism Single Nucleotide Structural equation modeling Article 03 medical and health sciences Genetic SDG 3 - Good Health and Well-being Genetic variation medicine Humans Genetic Predisposition to Disease Polymorphism Socioeconomic status 030304 developmental biology Genetic association Mental Disorders/genetics Depressive Disorder Major Depressive Disorder Models Genetic Genetic Variation Alcohol Drinking/genetics Heritability medicine.disease Mental health Comorbidity Genetic architecture Autism Spectrum Disorder/genetics Social Class Attention Deficit Disorder with Hyperactivity Schizophrenia Tourette Syndrome/genetics Smoking Cessation Anxiety Disorders/genetics 030217 neurology & neurosurgery Tourette Syndrome Genome-Wide Association Study Demography |
| Zdroj: | Nature Human Behaviour, 5(8), 1065-1073. Springer Nature Nature Human Behaviour, 5(8), 1065-1073. Nature Publishing Group Marees, A T, Smit, D J A, Abdellaoui, A, Nivard, M G, van den Brink, W, Denys, D, Galama, T J, Verweij, K J H & Derks, E M 2021, ' Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits ', Nature Human Behaviour, vol. 5, no. 8, pp. 1065-1073 . https://doi.org/10.1038/s41562-021-01053-4 Nature human behaviour |
| ISSN: | 2397-3374 |
| DOI: | 10.1101/2020.02.26.20028092 |
| Popis: | Epidemiological studies show high comorbidity between different mental health problems, indicating that individuals with a diagnosis of one disorder are more likely to develop other mental health problems. Genetic studies reveal substantial sharing of genetic risk factors across mental health traits. However, mental health is genetically correlated with socio-economic status (SES) and it is therefore important to investigate and disentangle the genetic relationship between mental health and SES. We used summary statistics from large genome-wide association studies (average N∼160,000) to estimate the genetic overlap across nine psychiatric disorders and seven substance use traits and explored the genetic influence of three different indicators of SES. Using Genomic SEM, we show significant changes in patterns of genetic correlations after partialling out SES-associated genetic variation. Our approach allows the separation of disease-specific genetic variation and genetic variation shared with SES, thereby improving our understanding of the genetic architecture of mental health. |
| Databáze: | OpenAIRE |
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