Nerve growth factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein, Vpr
| Autor: | Douglas W. Zochodne, Hanieh Jalali, Gia-Linh S. Luu, Jose A. Martinez, Russell Watts, Jihan Salame, Christine A. Webber, Araya Ruangkittisakul, Christopher Power, Klaus Ballanyi, Gui Fang Guo, Shaona Acharjee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Sensory Receptor Cells viruses Receptor expression Blotting Western Fluorescent Antibody Technique HIV Infections Mice Transgenic Tropomyosin receptor kinase A Biology Real-Time Polymerase Chain Reaction Article Rats Sprague-Dawley Mice Fetus Dorsal root ganglion Ganglia Spinal Internal medicine Nerve Growth Factor medicine Animals Humans Receptor trkA GSK3B Cells Cultured Acquired Immunodeficiency Syndrome General Neuroscience Axon extension virus diseases vpr Gene Products Human Immunodeficiency Virus Immunohistochemistry Rats Endocrinology Allodynia medicine.anatomical_structure Nerve growth factor nervous system Immunology Neuralgia medicine.symptom Signal transduction Signal Transduction |
| Zdroj: | Neuroscience. 252:512-525 |
| ISSN: | 0306-4522 |
| Popis: | Distal sensory polyneuropathy (DSP) with associated neuropathic pain is the most common neurological disorder affecting patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Viral protein R (Vpr) is a neurotoxic protein encoded by HIV-1 and secreted by infected macrophages. Vpr reduces neuronal viability, increases cytosolic calcium and membrane excitability of cultured dorsal root ganglion (DRG) sensory neurons, and is associated with mechanical allodynia in vivo. A clinical trial with HIV/AIDS patients demonstrated that nerve growth factor (NGF) reduced the severity of DSP-associated neuropathic pain, a problem linked to damage to small diameter, potentially NGF responsive fibers. Herein, the actions of NGF were investigated in our Vpr model of DSP and we demonstrated that NGF significantly protected sensory neurons from the effects of Vpr. Footpads of immunodeficient Vpr transgenic (vpr/RAG1−/−) mice displayed allodynia (p |
| Databáze: | OpenAIRE |
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