Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy
| Autor: | Bruce W. Keene, Sandy P. Tou, K. O’Donnell, Teresa C. DeFrancesco, Kathryn M. Meurs, Clarke E. Atkins, Darcy B. Adin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Population Cardiomyopathy macromolecular substances Biology Cat Diseases 03 medical and health sciences Genetics medicine Genetic predisposition Animals cardiovascular diseases education Genetic testing education.field_of_study CATS Myosin Heavy Chains medicine.diagnostic_test 0402 animal and dairy science Hypertrophic cardiomyopathy Genetic Variation 04 agricultural and veterinary sciences General Medicine Cardiomyopathy Hypertrophic medicine.disease 040201 dairy & animal science 030104 developmental biology Cats cardiovascular system Female Animal Science and Zoology MYH7 Carrier Proteins Purebred |
| Zdroj: | Animal Genetics. 52:542-544 |
| ISSN: | 1365-2052 0268-9146 |
| DOI: | 10.1111/age.13074 |
| Popis: | Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the domestic cat with a genetic predisposition in a few breeds. In the Maine Coon and Ragdoll breeds, two variants associated with the HCM phenotype have been identified in the cardiac myosin binding protein C gene (MYBPC3; p.Ala31Pro and p.Arg820Trp respectively), and a single variant has been identified in the myosin heavy chain gene (MYH7; p.Glu1883Lys) in one domestic cat with HCM. It is not known if these variants influence the development of HCM in other cohorts of the feline population. The objective of this study was to evaluate the presence of the known MYBPC3 and MYH7 variants in a population of cats with HCM. DNA was isolated from samples collected from non-Ragdoll and non-Maine Coon domestic cats diagnosed with HCM through the North Carolina State University College of Veterinary Medicine and genotyped for the three variants. One-hundred and three DNA samples from cats with HCM were evaluated from domestic shorthair, domestic longhair and purebred cats. All samples were wt for the MYBPC3 and MYH7 variants. Although this study was limited by its inclusion of cats from one tertiary hospital, the lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. Further studies to identify the causative variants for the feline HCM population are warranted. |
| Databáze: | OpenAIRE |
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