Boronate Affinity-Based Electrochemical Aptasensor for Point-of-Care Glycoprotein Detection

Autor:	Qiong Hu, Shuhan Hu, Shiqi Li, Sijie Liu, Yiyi Liang, Xiaojing Cao, Yilin Luo, Wanjing Xu, Haocheng Wang, Jianwen Wan, Wenxing Feng, Li Niu
Rok vydání:	2022
Předmět:	Limit of Detection Metallocenes Point-of-Care Systems Biosensing Techniques Electrochemical Techniques Gold Aptamers Nucleotide Electrodes Analytical Chemistry Glycoproteins
Zdroj:	Analytical chemistry. 94(28)
ISSN:	1520-6882
Popis:	As a class of oligosaccharide chain-containing proteins, glycoproteins are of great value in screening and early diagnosis of malignant tumors and other major diseases. Herein, we report a universal boronate affinity-based electrochemical aptasensor for point-of-care glycoprotein detection. Aptasensing of glycoproteins involves the specific recognition and capture of target glycoproteins by end-tethered nucleic acid aptamers and the site-specific labeling of ferrocene tags via the phenylboronic acid (PBA)-based boronate affinity interactions because the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16490cfad80031cae04bc730de07bb3e https://pubmed.ncbi.nlm.nih.gov/35793076 Zobrazit plný text záznamu