Conversion of D-fructose to 5-acetoxymethyl-2-furfural Using Immobilized Lipase and Cation Exchange Resin
| Autor: | Kyungwon Lee, Seunghan Shin, Se Won Bae, Jong Shik Shin, Nhan Thanh Thien Huynh, Yong Jin Kim, Jin Ku Cho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Immobilized enzyme
Pharmaceutical Science Fructose Furfural Article Catalysis Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine D-Fructose Organic chemistry Furaldehyde Dehydration Cation Exchange Resins Physical and Theoretical Chemistry Ion-exchange resin chemistry.chemical_classification Esterification Chemistry Organic Chemistry D fructose Immobilized lipase Lipase medicine.disease Enzymes Immobilized 5-Acetoxymethyl-2-furfural (AMF) Enzyme Chemistry (miscellaneous) dehydration trans-esterification Solvents Molecular Medicine 5-Hydroxymethyl-2-furfural (HMF) |
| Zdroj: | Molecules Volume 24 Issue 24 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24244623 |
| Popis: | 5-Acetoxymethyl-2-furfural (AMF) was prepared from D-fructose via 1,6-diacetylfructose (DAF) through a simple two-step reaction pathway. Immobilized enzyme (Novozym 435) was found to be the best enzymatic catalyst for the trans-esterification step (yielding 94.6% DAF). In the dehydration step, while soluble H2SO4 was found to be the best acidic catalyst (yielding 86.6% AMF), we opted to utilize heterogeneous cation exchange resin (Amberlyst 15) together with recyclable industrial solvents (1,4-dioxane) for a more sustainable AMF synthesis procedure. Although the total yield of AMF was a little lower, both the enzyme and the solid acid catalyst could be recycled for five cycles without a significant loss of activity, which has a major contribution to the cost-efficient aspect of the entire process. |
| Databáze: | OpenAIRE |
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