A health index to evaluate clinically a ß-hemolytic streptococcal infectious disease model in the horse
| Autor: | Jean D. Powers, Thomas E. Powers, S. L. Spurlock, K. J. Varma, A. A. Gabel |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pharmacology
medicine.medical_specialty General Veterinary business.industry Animal disease Streptococcus Horse Penicillin G Streptococcal infectious disease Microbial Sensitivity Tests Disease Surgery Efficacy Clinical trial Disease Models Animal Health index Streptococcal Infections Animals Medicine Horse Diseases Statistical analysis Horses business Intensive care medicine |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 7:213-217 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1111/j.1365-2885.1984.tb00902.x |
| Popis: | Quantification of the clinical manifestations of a disease has been a serious problem particularly as related to clinical trials or drug efficacy studies. Historically, this quantification has been limited to categorizing each patient into one of three or four groups, e.g. worse, no improvement, improved. This problem becomes serious when an investigation utilizes an experimentally induced animal disease model. A health index, which quantifies the clinical state of horses which have an experimentally induced s-hemolytic streptococcal infection, is described. Aspects of experimental design and statistical analysis are also discussed in relationship to the use of the index for drug efficacy studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text