The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
| Autor: | Miriam Scicchitano, Francesca Bosco, Federica Scarano, Rocco Mollace, Micaela Gliozzi, Roberta Macrì, Vincenzo Mollace, Stefano Ruga, Francesca Oppedisano, Carolina Muscoli, Maria Caterina Zito, Sara Paone, Jessica Maiuolo, Cristina Carresi, Ernesto Palma, Saverio Nucera, Vincenzo Musolino |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Nervous system
Male Diabetic neuropathy erectile dysfunction Inflammation Review Catalysis endothelial dysfunction Inorganic Chemistry lcsh:Chemistry nitric oxide synthase (NOS) Diabetic Neuropathies Peripheral Nerve Injuries Blood Nerve Barrier (BNB) nitric oxide medicine Animals Humans peripheral nerve injury Endothelium Physical and Theoretical Chemistry Endothelial dysfunction Molecular Biology lcsh:QH301-705.5 Spectroscopy neuropathic pain Blood-Nerve Barrier business.industry Organic Chemistry General Medicine medicine.disease diabetic neuropathy Computer Science Applications Peripheral medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Peripheral nerve injury Neuralgia Sciatic nerve medicine.symptom Nitric Oxide Synthase business Neuroscience |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 12, p 3022 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | The exchange of solutes between the blood and the nerve tissue is mediated by specific and high selective barriers in order to ensure the integrity of the different compartments of the nervous system. At peripheral level, this function is maintained by the Blood Nerve Barrier (BNB) that, in the presence, of specific stressor stimuli can be damaged causing the onset of neurodegenerative processes. An essential component of BNB is represented by the endothelial cells surrounding the sub-structures of peripheral nerves and increasing evidence suggests that endothelial dysfunction can be considered a leading cause of the nerve degeneration. The purpose of this review is to highlight the main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve. |
| Databáze: | OpenAIRE |
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