Resection of Non-Functional Pancreatic Neuroendocrine Neoplasms—A Single-Center Retrospective Outcome Analysis
| Autor: | Jens Hoeppner, Birte Kulemann, Lars Tharun, Kirsten Lindner, Tobias Keck, Judith Gebauer, Dominik M. Schulte, Daniel Binte, Inga Buchmann, Ulrich F. Wellner, Kim Barbara Luley, Sebastian M. Schmid |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Future studies Non functional Outcome analysis Single Center Gastroenterology Article Resection Pancreatectomy pancreatic fistula Internal medicine postoperative complications Tumor Grading medicine Humans RC254-282 Retrospective Studies business.industry G2 pNEN Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged medicine.disease Pancreatic Neoplasms Pancreatic Neuroendocrine Neoplasm Neuroendocrine Tumors Pancreatic fistula outcome Neoplasm Recurrence Local pancreatic neuroendocrine neoplasm business |
| Zdroj: | Current Oncology Volume 28 Issue 4 Pages 268-3080 Current Oncology, Vol 28, Iss 268, Pp 3071-3080 (2021) |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol28040268 |
| Popis: | Surgery remains the only curative treatment of pancreatic neuroendocrine neoplasms (pNEN). Here, we report the outcome after surgery for non-functional pNEN at a European Neuroendocrine Tumor Society (ENETS) center in Germany between 2000 and 2019 cases were analyzed for surgical (Clavien–Dindo classification CDc) and oncological outcomes. Forty-nine patients (tumor grading G1 n = 25, G2 n = 22, G3 n = 2), with a median age of 56 years, were included. Severe complications (CDc ≥ grade 3b) occurred in 11 patients (22.4%) and type B/C pancreatic fistulas (POPFs) occurred in 5 patients (10.2%) in-hospital mortality was 2% (n = 1). Six of seven patients with tumor recurrence (14.3%) had G2 tumors in the pancreatic body/tail. The median survival was 5.7 years (68 months [1–228 months]). Neither the occurrence (p = 0.683) nor the severity of complications had an influence on the relapse behavior (p = 0.086). This also applied for a POPF (≥B, p = 0.609). G2 pNEN patients (n = 22) with and without tumor recurrence had similar median tumor sizes (4 cm and 3.9 cm, respectively). Five of the six relapsed G2 patients (83.3%) had tumor-positive lymph nodes (N+) all G2 pNEN patients with recurrence had initially been treated with distal pancreatic resection. Pancreatic resections for pNEN are safe but associated with relevant postoperative morbidity. Future studies are needed to evaluate suitable resection strategies for G2 pNEN. |
| Databáze: | OpenAIRE |
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