Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis
| Autor: | Klio Papadopoulou, H. Dimitroula, Georgios Koliakos, Despina G. Parcharidou, T. Sfetsios, Alexandros Garyfallos, Theodoros Dimitroulas, Ioannis H. Styliadis, Loukas Settas, Georgios Giannakoulas, Haralambos Karvounis |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Elevated pulmonary artery pressure medicine.drug_class Hypertension Pulmonary Ventricular Dysfunction Right Population Blood Pressure Pulmonary Artery Arginine Rheumatology Tissue Doppler echocardiography Predictive Value of Tests medicine.artery Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans cardiovascular diseases Heart Atria Prospective Studies education Aged Ultrasonography education.field_of_study Scleroderma Systemic business.industry General Medicine Middle Aged medicine.disease Pulmonary hypertension Peptide Fragments Blood pressure Cross-Sectional Studies Heart failure Pulmonary artery Multivariate Analysis Cardiology Female business Biomarkers Follow-Up Studies |
| Zdroj: | Clinical rheumatology. 29(9) |
| ISSN: | 1434-9949 |
| Popis: | Early detection of pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) is essential as it leads to substantial morbidity and mortality irrespective of its etiology. The aim of our study was to determine whether noninvasive biochemical and/or echocardiographic indices can predict the presence of PH in these patients. We prospectively studied 66 patients (mean age of 57.7 ± 12.1 years, 63 women) with SSc without clinical manifestations of heart failure. All patients underwent standard and tissue Doppler echocardiography. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) and asymmetric dimethylarginine (ADMA) levels were also measured. In 24 (36%) patients, the diagnosis of PH was established by echocardiography (systolic pulmonary artery pressure value ≥40 mmHg). Left atrial (LA) volume, NT-proBNP, ADMA, ratio of early transmitral filling velocity to early diastolic velocity of the mitral annulus (mitral E/E m), and right ventricular myocardial performance index (MPI) were univariate predictors of PH. In multivariate analysis, NT-proBNP, LA volume, and right ventricular MPI were independent predictors of PH in SSc patients. LA volume and NT-proBNP may be useful noninvasive markers for the prediction of elevated pulmonary artery pressure in patients with SSc. These parameters should be considered when assessing this population for risk stratification and for identification of patients demanding further investigation and institution of specific therapy for the disease at the time when it is most likely to be effective. |
| Databáze: | OpenAIRE |
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