Natural products and phytochemicals as potential anti‐SARS‐CoV ‐2 drugs
| Autor: | Manoj Garg, Bhudev C. Das, Namrata Dudha, Myriam Merarchi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
coronaviruses
viruses In silico Phytochemicals Reviews Review Antiviral Agents SARS‐CoV‐2 Virus Microbiology MERS‐CoV 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine prevention COVID‐19 RNA polymerase natural compounds RNA‐Virus Humans Pharmacology Serine protease therapy Biological Products 0303 health sciences biology SARS-CoV-2 030302 biochemistry & molecular biology SARS‐CoV RNA RNA virus biology.organism_classification COVID-19 Drug Treatment chemistry Viral replication 030220 oncology & carcinogenesis biology.protein Tripterygium wilfordii Drugs Chinese Herbal |
| Zdroj: | Phytotherapy Research |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.7151 |
| Popis: | The current pandemic responsible for the crippling of the health care system is caused by the novel SARS-CoV-2 in 2019 and leading to coronavirus disease 2019 (COVID-19). The virus enters into humans by attachment of its Spike protein (S) to the ACE receptor present on the lung epithelial cell surface followed by cleavage of S protein by the cellular transmembrane serine protease (TMPRSS2). After entry, the SARS-CoV-2 RNA genome is released into the cytosol, where it highjacks host replication machinery for viral replication, assemblage, as well as the release of new viral particles. The major drug targets that have been identified for SARS-CoV-2 through host-virus interaction studies include 3CLpro, PLpro, RNA-dependent RNA polymerase, and S proteins. Several reports of natural compounds along with synthetic products have displayed promising results and some of them are Tripterygium wilfordii, Pudilan Xiaoyan Oral Liquid, Saponin derivates, Artemisia annua, Glycyrrhiza glabra L., Jinhua Qinggan granules, Xuebijing, and Propolis. This review attempts to disclose the natural products identified as anti-SARS-CoV-2 based on in silico prediction and the effect of a variety of phytochemicals either alone and/or in combination with conventional treatments along with their possible molecular mechanisms involved for both prevention and treatment of the SARS-CoV-2 disease. |
| Databáze: | OpenAIRE |
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