CGP 43371 paradoxically inhibits development of rabbit atherosclerotic lesions while inducing extra-arterial foam cell formation
| Autor: | David Louis Feldman, Michael Jeune, Therese C Mogelesky, Margaret F. Prescott, Jean Von Linden-Reed, W. K. Sawyer |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Very low-density lipoprotein medicine.medical_specialty Arteriosclerosis Lipoproteins Spleen Aorta Thoracic Biology Cholesterol Dietary Rats Sprague-Dawley chemistry.chemical_compound High-density lipoprotein medicine.artery Internal medicine medicine Thoracic aorta Animals Foam cell Aorta Cholesterol Anticholesteremic Agents Surgery Rats medicine.anatomical_structure Endocrinology chemistry Liver lipids (amino acids peptides and proteins) Rabbits Peritoneum Rifampin Cardiology and Cardiovascular Medicine Cell Division Lipoprotein Foam Cells |
| Zdroj: | Atherosclerosis. 154(2) |
| ISSN: | 0021-9150 |
| Popis: | Ansamycins are hypolipidemic compounds which, when administered to various animal species, dramatically lower high density lipoprotein (HDL) cholesterol levels, in addition to reducing the levels of other lipoprotein classes. The current study tested one of these ansamycins (CGP 43371) for its hypolipidemic and anti-atherosclerotic activity in cholesterol-fed rabbits. Rabbits were fed a 0.25% cholesterol-enriched diet with or without admixed CGP 43371, equivalent to 30 mg/kg per day for 16 weeks. Compared with control rabbits, CGP 43371 treatment lowered total cholesterol levels (46%, P |
| Databáze: | OpenAIRE |
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