Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus
| Autor: | Victoria H. Woolner, Rose M. A. Gordon, Peter T. Northcote, Robert A. Keyzers, Matthias Lein, John H. Miller |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Pacific Ocean Halogenation 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Pharmaceutical Science HL-60 Cells Callophycus serratus 010402 general chemistry 01 natural sciences Leukemia cell line Callophycus 0104 chemical sciences Analytical Chemistry Scalar coupling Complementary and alternative medicine Rhodophyta Drug Discovery Humans Molecular Medicine Diterpenes |
| Zdroj: | Journal of Natural Products. 81:2446-2454 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A detailed examination of the red alga Callophycus serratus collected in Tonga led to the isolation of six new halogenated meroditerpenoids: callophycol C (1), callophycoic acid I (2), iodocallophycols E (3) and F (4), iodocallophycoic acid B (5), and callophycoic acid J (6). Of these, compounds 3–5 are new iodinated additions to the growing family of Callophycus meroditerpenoids. The relative configurations of compounds 1–6 were deduced by analyses of 1D NOE data and 1H–1H scalar coupling constants, and 3–6 are proposed to differ from the closely related compounds reported in the literature, iodocallophycoic acid A and iodocallophycols A–D. Iodocallophycol E (3) exhibited moderate cytotoxicity against the promyelocytic leukemia cell line HL-60 with an IC50 value of 6.0 μM. |
| Databáze: | OpenAIRE |
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