Bone marrow–derived cells from male donors can compose endometrial glands in female transplant recipients
| Autor: | Masahiro Takakura, Yoshiko Maida, Satoru Ozaki, Tomomi Ikoma, Masaki Inoue, Shinji Nakao, Satoru Kyo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stromal cell Hormone Replacement Therapy Biopsy medicine.medical_treatment Bone Marrow Cells In situ hybridization Endometrium Sex Factors medicine Humans Bone Marrow Transplantation business.industry Obstetrics and Gynecology Bone Marrow Stem Cell Cell Differentiation Hormone replacement therapy (menopause) Tissue Donors Transplantation medicine.anatomical_structure Immunology Female Bone marrow Stem cell business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 201:608.e1-608.e8 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2009.07.026 |
| Popis: | Objective For continuous regeneration of human endometrium in menstrual cycles, endometrial stem cells are assumed to supply differentiating endometrial glandular cells. To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who received bone marrow transplantation from male donors. Study Design Endometrial specimens biopsied after hormone replacement therapy were obtained and examined using fluorescent in situ hybridization analysis targeting X or Y chromosomes. Results All recipients had donor-derived Y chromosome–positive endometrial cells, accounting for 0.6-8.4% of glandular epithelial cells and 8.2-9.8% of stromal cells. Most of the endometrial glands were chimeric, consisting of both donor-derived and recipient cells. Conclusion Donor-derived cells are capable of composing endometrium in recipients, even those of the opposite sex. These results suggest unexpected plasticity of bone marrow stem cells as well as a potential origin of endometrial stem cells. |
| Databáze: | OpenAIRE |
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