Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients
| Autor: | Toshifumi Wakai, Junko Tsuchida, Yu Koyama, Yoshifumi Shimada, Takashi Kobayashi, Kohei Miura, Hiroshi Ichikawa, Masato Nakajima, Takaaki Hanyu, Masato Nakano, Shin-ichi Kosugi, Jun Sakata, Kazuki Moro, Hitoshi Kameyama, Masayuki Nagahashi, Mayuko Ikarashi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Inflammatory reaction Colorectal cancer n-6 polyunsaturated fatty acid Gastroenterology C-reactive protein 03 medical and health sciences Carnitine Internal medicine Statistical significance Lipid emulsion medicine Prospective randomized study 030109 nutrition & dietetics biology business.industry General Medicine Parenteral nutrition medicine.disease Surgery biology.protein Original Article business Surgical patients medicine.drug |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| Popis: | Background: A prospective randomized study was performed to investigate the validity of intravenous carnitine administration during postoperative parenteral nutrition (PN) with lipid emulsion. Methods: Patients undergoing surgery for gastric or colorectal cancer were enrolled in the study and were randomly divided into two groups (n = 8 in each group): 1) group L, who received a peripheral PN (PPN) solution of 7.5% glucose, 30% amino acid, and 20% lipid emulsion; and 2) group LC, who received the same PPN solution, as well as carnitine intravenously. PPN was performed from postoperative day (POD) 1 to POD4. Clinical and laboratory parameters were compared between the two groups; statistical significance was set at P < 0.05. Results: Serum carnitine concentrations were significantly higher in group LC on POD3 (P < 0.01) and POD7 (P = 0.01). Postoperative changes in laboratory parameters and morbidity were comparable between the two groups. However, the decrease in C-reactive protein from POD3 to POD7 was significantly greater in group LC than in group L (P = 0.011). Conclusion: The results show that intravenous carnitine administration in addition to PN is safe and may be beneficial for recovery from postoperative inflammatory reactions. J Clin Med Res. 2017;9(10):831-837 doi: https://doi.org/10.14740/jocmr3113w |
| Databáze: | OpenAIRE |
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